Prolotherapy Research

Prolotherapy Definition: Injection to stimulate healing of soft tissue. 

Types of Prolotherapy:  Enthesofascial, myofascial and neurofascial (See recent talk  for explanation)

Site Administrator: K. Dean Reeves, M.D., AAPM&R, Clinical Associate Professor, University of Kansas.   DeanReevesMD@gmail.com  (913) 362 1600

Short summaries of various topics are available  at  http://getprolo.com . These are very useful for introduction to general concepts.  These opinion papers do not cite research heavily but are very readable and useful for introductions to a variety of pain conditions. 

For those interested in method articles and some retrospective journal research -  not peer reviewed but accessibly written -   the Journal of Prolotherapy is an excellent source.   Navigate to  http://journalofprolotherapy.com  

 

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General Prolotherapy Articles

General Prolotherapy Summary  Reeves KD Sweet Relief: "Prolotherapy Targets Sprains and Strains". Biomechanics 2004(9):24-35.  

 

 

 

 

Musculoskeletal Prolotherapy    Alderman D. "Prolotherapy for Musculoskeletal Pain". Practical Pain Management 2007 (Jan-Feb):10-15. 

 

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Books on Prolotherapy for Easy Reading

The Cure For Chronic Pain  Moore Nancy S. Moore.   2009. Available at  http://www.natural-healing-health.com

 

 

Articles by Topic 

 

Knee Arthritis Alderman D.  "Prolotherapy for Knee Pain"  Practical Pain Management 2007 (Jul): 70-79. 

 

 

 

 

Low Back Pain Article   Alderman D. Prolotherapy for Musculoskeletal Pain. Practical Pain Management 2007 (July):58-63.  

 

 

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Neck Pain: Hauser RA, Hauser MA. Practical Pain Management 2007 (Oct):56-69. 

 

 

 

 

TMJ pain:  Hauser RA, Hauser MA, Blakemore KA. Practical Pain Management 2007 (Nov-Dec):49-55. 

 

 

 

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 Other Review Articles in Pub Med Literature  (technical language)

 

 

Other Comments:

Glucose Structure 

For those interested in what dextrose is, Wikipedia offers a nice picture.  It is a simple and powerful structure, a placebo by mouth, but able to stimulate production of repair proteins within minutes of injection in high concentration. "Glucose (also known as dextrose) is a monosaccharide - formula C6H12O6. It is an example of a 6-carbon (hexose) sugar.  Notice the 6 carbon atoms (grey) forming the backbone of the molecule, and the oxygen atom (red) in the ring.  The hydrogen atoms (white) are either attached directly to the carbons, or via oxygen as OH groups - at an angle.  The ring itself is 6-sided, but only 5 of its corners are made up by carbon atoms. Only the carbon outside the ring ( number 6) has 2 single hydrogens and an OH group.  The glucose molecule can form into other configurations, but this structure (á-D-glucopyranose!) is the most stable and therefore most common in biological systems."